Improving brain cancer treatments


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This project focuses on improving treatment and survival for children with some of the most high-risk brain cancers.

Pharmaco-phospho-proteo-genomics of paediatric high-grade glioma (HGG)

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Brain cancer accounts for 40 percent of paediatric cancer deaths. There has been no significant improvement in survival rates in decades. High-grade gliomas (HGG) are particularly aggressive and deadly brain tumours.

Genetic mutations alter the activity of proteins controlling the growth and survival of cancer cells. For children diagnosed with HGG, we are yet to understand how these pathways function.

This project, led by Associate Professor Matt Dun, will combine the investigation of tumour genomics and protein architecture to establish patient-specific therapeutic options with the greatest chance of survival.


Associate Professor Matt Dun


The University of Newcastle, Hunter Medical Research Institute


$400,000 October 2021 to September 2024

Associate Professor Matt Dun
Professor Matt Dun

Thank you from the researcher

Associate Proffessor Matt Dun is an NHMRC research fellow from The University of Newcastle in the Shcool of Biomedical Sciences and Pharmacy. He has been supported by TKCP since October of 2021.

Assoc. Prof. Dun has personal experience of childhood cancer with his daughter affected. Matt's daughter Josie was diagnosed with deadly brain stem cancer, Diffuse Instrinsic Pontine Glioma (DIPG) at 2 years of age. Josie died 22 months later. 

This experience saw Dr Dun shift focus from blood cancer to brain cancers where he continues his research efforts to increase understanding regarding the pathophysiology of the disease and improve survivability.

Researcher Profile

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