Enhanced polyamine depletion for aggressive childhood cancers

Enhanced polyamine depletion for aggressive childhood cancers

Institute: Children’s Cancer Institute
Recipient: Professor Michelle Haber
Funding: $239,995 July 2019 to June 2023

The overarching aim of this project is to improve the efficacy of current therapeutics and move this research into clinical trials of children with aggressive cancers.

Data from the Haber laboratory indicates that polyamine depletion is an exciting new treatment opportunity for children with high-risk neuroblastomas and paediatric brain tumours, who would otherwise have a dismal outcome.

Behind the Science: Professor Michelle Haber

In this project, Professor Haber and her team will use preclinical models to define the optimal combinations of polyamine depletion, chemotherapy and immunotherapy that can rapidly translate to the bedside.

When completed, this project will have produced considerable experimental data required for clinical trials to help kids diagnosed with high-risk neuroblastoma and the most aggressive types of brain tumours including diffuse intrinsic pontine glioma (DIPG), for which the survival rate is currently zero.

This project received further support through Cancer Australia's Priority-driven Collaborative Cancer Research Scheme.