Application of gene-silencing nanodrugs to inhibit medulloblastoma growth

Application of gene-silencing nanodrugs to inhibit medulloblastoma growth

Institute: Children’s Cancer Institute
Recipient: Associate Professor Joshua McCarroll
Funding: $298,554 July 2019 to June 2023

Medulloblastoma is the most common malignant brain cancer diagnosed in children.

Chemoresistance and relapse are key reasons why brain cancer is the disease that kills more Australian children than any other.

Behind the science: Associate Professor Joshua McCarroll

It’s widely known that a major limitation for effective treatment is the presence of the blood-brain-barrier (BBB), which restricts entry of therapeutic drugs into the brain. That’s where Associate Professor McCarroll’s research comes in.
His team will to use state-of-the-art tiny nanomedicines designed to cross the BBB and selectively penetrate brain tumours and inhibit a gene which plays an important role in regulating chemosensitivity without causing toxicity to non-tumour cells. 
If successful, this new therapeutic strategy has the potential to increase survival and quality of life for children diagnosed with all types of brain cancer.
This project received further support through Cancer Australia's Priority-driven Collaborative Cancer Research Scheme.