Recipient: Dr Bryan Day
Institute: QIMR Berghofer Medical Research Institute
Funding: $208,549 July 2014 to June 2015 and July 2017 to June 2018
Funding partner: This project is supported by a donor of The Kids' Cancer Project
Dr Day aims to determine what function Eph receptors play in medulloblastoma cells and whether they can be used as new therapeutic targets.

Dr Bryan Day from the QIMR Berghofer Medical Research Institute in Brisbane has been investigating the role of a group of proteins in paediatric medulloblastoma, a fast-growing, high-grade brain tumour that most commonly affects children, but can affect adults too. The proteins, known as Eph receptors, are not usually present in normal healthy tissue but are found in a number of cancers, including adult brain cancer where they have been shown to contribute to aggressiveness.

With highly encouraging results to date, further funding by The Kids’ Cancer Project will allow an expanded scope of these studies. Work to be conducted during the funding period will include validation that the antibody-based approach is effective in all four medulloblastoma molecular subgroups, and that it can be used in combination with chemotherapy and radiation. If effective, this could lead to clinical testing of these novel therapies in children with medulloblastoma.

“Sadly, too many children are still dying of brain cancer.” - Dr Bryan Day
Science is the solution for kids with cancer
The only way to improve outcomes for children diagnosed with cancer is through advances in medical research. Every day and every donation takes us closer to a cure.
Select your donation details
Please enter the amount you would like to donate

The Kids' Cancer Project is an ACNC Registered Charity 
ABN 13 061 138 181 | CFN 10581